Guest post from Holly Salisbury, Royal Society of Chemistry

We challenged early career researchers to explain the importance of chemistry to human health in just 1 minute. The shortlisted videos are now online and we want YOU to pick your favourite entry.

The chemical sciences will be fundamental in helping us meet the healthcare challenges of the future, and we are committed to ensuring that they contribute to their full potential. As part of our work in this area, we invited undergraduate and PhD students, post-docs and early career researchers to produce an original video that demonstrates the importance of chemistry in health.

We were looking for imaginative ways of showcasing how chemistry helps us address healthcare challenges and entries could be no more than 1 minute long.

The winner will receive a £500 cash prize, with a £250 prize for second place and £150 prize for third place up for grabs too.

We want you to get involved: watch our 6 shortlisted videos and vote for your favourite before 11.59pm (GMT) 17 April 2015! (more…)

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Guest post by Heather Cassell

One of the great joys of being in the lab is being in charge of your own experiments, from designing what you want to study to the interpretation of the results. Having responsibility for your work from conception to completion is challenging and ultimately rewarding.

The first step in designing your experiment is to find out what you want to know. That sounds simple and obvious, but it really is key to providing focus when planning your work. You must consider why you are doing this experiment, what it could show, how it fits with your other work, and, importantly, will you be able to interpret the results in a meaningful way, providing answers you can build on?

Inspiration for your experiments can come from diverse sources, beyond the traditional scientific lectures or academic literature, a conversation with a current or former colleague can be all it takes. But whatever the source of the idea, it is always a good idea to check if anyone else has beaten you to it by consulting the literature. Not that repeating existing work is a bad idea – you can see if existing studies are reproducible and if so, embellish or add to the data. Or you can change the design of your experiment to fit with your own previous studies, and may find something new. (more…)

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Guest post by Rowena Fletcher-Wood

A carbon nanotube, animated by Schwarzm, and released here under a CC-BY-SA licence

If necessity is the mother of invention, discovery is more than fuelled by fashion. After the 1985 groundbreaking discovery of the buckminsterfullerene, the ground for stable carbon allotropes with interesting shapes and properties was just that – broken. In 1990, Richard Smalley postulated the existence of carbon nanotubes as long, extended hexagon-based versions of C60, or ’buckytubes’. Carbon dirt had never looked so good before, and the mucking about began.

Graphene flakes were first isolated at Manchester University by Andre Geim and Konstantin Novoselov in 2003, when they noticed the technique surface scientists were using to clean graphite samples – peeling off the contaminated upper layer using pieces of sellotape. The pieces of sellotape went in the bin, but Geim and Novoselov fished them out again – and started painstakingly peeling off thinner and thinner layers until they made 1 atom thick graphene. They were awarded the Nobel prize for physics in 2010. (more…)

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Last week, we heard from Derek Lowe about the evocative smells associated with working in the lab. Inspired by Derek’s olfactory adventures, the Chemistry World and Education in Chemistry teams shared their own experiences.

This week, we hear from our regular guest bloggers Tom Branson, Heather Cassell, JessTheChemist and Rowena Fletcher-Wood about their own smelly memories, along with a few more from the #labsmells hashtag.

Rowena Fletcher-Wood

Chemistry has ruined me for marzipan.

Not just marzipan, of course, almonds, almond flavouring, even apricots. If you waft a piece of almond cake under my nose unexpectedly, I will automatically give an sudden and violent sniff, and recoil physically. I can’t help it, it’s an instinct, and that smell is the smell of hydrogen cyanide. (more…)

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M-H Jeeves

In this month’s Chemistry World, Derek Lowe writes about the memorable smells associated with a career in chemistry, including the fragrantly fruity funk of esters and the suspicious seaside stench of amines.

Inspired by Derek’s olfactory adventures, I asked a few of the Chemistry World and Education in Chemistry team to recount their own experiences of lab smells, and opened it up to the twittersphere under the hashtag #labsmells:

Philip Robinson, Deputy Editor, Chemistry World

As a PhD student in the ‘dry’ half of a biochemical NMR group, most lab smells were associated with a sense of relief that I was at last free of the chaotic caprice of real chemistry. But on occasional trips down the corridor to see how the other half lived I’d often encounter the bold odour of the yeast cultures that were busily building our proteins.

(more…)

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Guest post from Tom Branson

Last month I took a look back at the journal covers from Chemical Science in 2014 and asked the authors why they made these startling images. To follow on from these enlightening insights, I delved a little deeper and sought to find an answer to the ultimate question, which is of course: what makes a good journal cover?

Scientific and public audiences

To answer this question you first have to decide who the target audience(s) are and what you want to show them. Most of the authors I spoke to agreed that the image should be accessible to the general public. Julia Weinstein from the University of Sheffield, UK, whose cover was out last March, expressed the difficulty in also keeping the specialists happy. An image needs to have ‘general importance (for general public), and some fine details which will be of interest to professionals. It is a virtually impossible task!’ she said. However, how many members of the general public ever actually see these masterpieces is a question for another time. (more…)

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Guest post by JessTheChemist

’I feel like I’d like to lead one more life. I’d like to leave a cultural imprint on society rather than just a technological benefit’ – Carl Djerassi

May you rest in peace, Carl Djerassi (October 29, 1923 – January 30, 2015).

The so-called ’father of the pill’ [he preferred ‘the mother of the pill’, as he saw himself nurturing the chemical ‘egg’ to bring forth the pill], Carl Djerassi, died recently at the age of 91 after a battle with cancer. Djerassi had a varied career involving both the sciences and the arts, contributing in particular to the fields of natural product chemistry, including antihistamines and pesticides, and spectroscopy. In 1951 Djerassi and his co-workers completed the synthesis of the first synthetic oral contraceptive, norethindrone or ’the pill’ and, due to the work by John Rock; by 1960 the pill was approved by the Food and Drug Administration for contraceptive use.

Djerassi was awarded a wealth of accolades for his contributions to the field of chemistry, from the Wolf prize in chemistry (1978) to the Priestley medal (1992); however, the Nobel prize in chemistry is a notable omission. Every year the twittersphere is awash with debates about the next Nobel prize in chemistry winner should be and Djerassi’s name is always top of the list, and my personal front-runner. The last will of Alfred Nobel stated that prizes should be given ’to those who, during the preceding year, shall have conferred the greatest benefit to mankind’. To say that the pill is of benefit to man- and womankind is an understatement and Djerassi should have been honoured many years ago by the Nobel Committee. As a small gesture to the man and his ground-breaking work, I shall celebrate him here. This blog series is focussed on the academic relationships of Nobel Prize winners, I’ve made an exception for a man who has had an enormous influence on my life and that of many other women around the world. (more…)

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Guest post by Heather Cassell

In the lab, you develop a fondness for working with certain things: compliant equipment, pleasant smelling solvents, easy-to-culture bacteria. One of my favourites are fluorescent proteins – their bright colours can make even the dullest day that little bit more cheery. I find them a joy to work with not only because of their beauty, but because the source of that beauty also makes them easy to work with.

A San Diego beach scene drawn with an eight colour palette of bacterial colonies expressing fluorescent proteins derived from GFP and the red-fluorescent coral protein dsRed. The colors include BFP, mTFP1, Emerald, Citrine, mOrange, mApple, mCherry and mGrape. Artwork by Nathan Shaner, photography by Paul Steinbach, created in the lab of Roger Tsien in 2006. (CC-BY-SA)

A good example of this is in protein production. During expression in E. coli, you often cannot tell how well expression of a colourless protein is going, but because fluorescent proteins will produce a colour even at a relatively low concentrations, it can be seen while the cells are still growing. This allows you to keep track of your progress, answering key questions like: do I have any protein? Or did I add the chemical I need to produce the protein? (The latter being a not uncommon mistake for a sleep-deprived scientist.) Getting answers to these visually means no lengthy purification procedure, avoiding the inevitable disappointment.

The colouration continues to be helpful as you go through the protein purification process: you can easily see if your protein has been released from the cells, whether it has bound to the column, if it has been released from the column and so on. Again, each of these steps requires another means of detection in colourless proteins. (more…)

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Guest post by Isobel Hogg, Royal Society of Chemistry

Can you explain the importance of chemistry to human health in just 1 minute? If you’re an early-career researcher who is up to the challenge, making a 1 minute video could win you £500.

We are looking for imaginative ways to showcase how chemistry helps us address healthcare challenges. Your video should be no longer than one minute, and you can use any approach you like.

The winner will receive a £500 cash prize, with a £250 prize for second place and £150 prize for third place up for grabs too. (more…)

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Guest post by Rowena Fletcher-Wood

Open your eyes and take a closer look: sometimes that’s all it takes to realise a new invention has been with you all along, stuck, perhaps, to the cuffs of your trousers and the fur of your pointer. Like the burrs of the burdock, evolved to stick to the fur of animals, transporting the seeds far and wide to fall on new ground.

Swiss amateur mountaineer Georges de Mestral had been hunting in the French Alps one summer evening in 1948, when exactly this occurred. He had obviously encountered burrs before, but for the first time his mind connected an observation (the sticky burrs) and an application (fashion) – it was a scientific portmanteau or ‘blend’ of two ideas, contracting their meanings into a single new commodity: Velcro. The name is a portmanteau too, a combination of the French words velour and crochet: the soft fabric side and the hooked. De Mestral had stumbled upon a new way of fixing clothing, but was it such an accident? Louis Pasteur, scientist and inventor of the Pasteurisation process, famously said ‘in the fields of observation, chance favours only the prepared mind.’ He had a point. (more…)

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