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Chemistry World was delighted to sponsor a poster prize at ISACS16 (Challenges in Chemical Biology), held in Zurich, Switzerland, last month. Oliver Thorn-Seshold was the winner with his poster entitled ‘Photoswitchable inhibitors of microtubule dynamics: Photostatins optically control mitosis and cell death.’
Oliver explains his work:
‘My motivation was to take a shot at curative tumour chemotherapy, based on a mechanism that has not been explored for drugs before – reversibly light-targetable cytotoxins.
The idea is to apply the drug globally in the patient, but activate it locally in the tumour by illuminating the tumour zone with pulses of blue light. Outside the tumour zone, the drug should remain inactive. One could therefore use higher doses than conventionally possible, so therapeutic effectiveness can be improved whilst limiting side effects.